Rujipas SirijatuphatYupin SuputtamongkolNasikarn AngkasekwinaiNavin HorthongkhamMethee ChayakulkeereePinyo RattanaumpawanPornpan KoomanachaiSusan AssanasenYong RongrungruangNitipatana ChierakulRanistha RatanaratAnupop JitmuangWalaiporn WangchindaWannee KantakamalakulSiriraj Hospital2022-08-042022-08-042021-12-01BMC Infectious Diseases. Vol.21, No.1 (2021)147123342-s2.0-85104863961https://repository.li.mahidol.ac.th/handle/20.500.14594/77597Background: The epidemiology and outcomes of COVID-19 patients in Thailand are scarce. Methods: This retrospective cohort study included adult hospitalized patients who were diagnosed with COVID-19 at Siriraj Hospital during February 2020 to April 2020. Results: The prevalence of COVID-19 was 7.5% (107 COVID-19 patients) among 1409 patients who underwent RT-PCR for SARS-CoV-2 detection at our hospital during the outbreak period. Patients with COVID-19 presented with symptoms in 94.4%. Among the 104 patients who were treated with antiviral medications, 78 (75%) received 2-drug regimen (lopinavir/ritonavir or darunavir/ritonavir plus chloroquine or hydroxychloroquine), and 26 (25%) received a 3-drug regimen with favipiravir added to the 2-drug regimen. Disease progression was observed in 18 patients (16.8%). All patients with COVID-19 were discharged alive. Conclusions: The prevalence of COVID-19 was 7.5% among patients who underwent RT-PCR testing, and 10% among those having risk factors for COVID-19 acquisition. Combination antiviral therapies for COVID-19 patients were well-tolerated and produced a favorable outcome.Mahidol UniversityMedicineArticleSCOPUS10.1186/s12879-021-06081-z