Thongprayoon C.Cheungpasitporn W.Radhakrishnan Y.Zabala Genovez J.L.Petnak T.Shawwa K.Qureshi F.Mao M.A.Kashani K.B.Mahidol University2023-06-182023-06-182022-12-01Therapeutic Apheresis and Dialysis Vol.26 No.6 (2022) , 1098-110517449979https://repository.li.mahidol.ac.th/handle/20.500.14594/85348Introduction: We aimed to assess the association between serum potassium and mortality in patients receiving continuous renal replacement therapy (CRRT). Methods: We studied 1279 acute kidney injury patients receiving CRRT in a tertiary referral hospital in the United States. We used logistic regression to assess the association of serum potassium before CRRT and mean serum potassium during CRRT with 90-day mortality after CRRT initiation, using serum potassium 4.0–4.4 mmol/L as reference group. Results: Before CRRT, there was a U-shaped association between serum potassium and 90-day mortality. There was a significant increase in mortality when serum potassium before CRRT was ≤3.4 and ≥4.5 mmol/L. During CRRT, progressively increased mortality was noted when mean serum potassium was ≥4.5 mmol/L. The odds ratio of 90-day mortality was significantly higher when mean serum potassium was ≥4.5 mmol/L. Conclusion: Hypokalemia and hyperkalemia before CRRT and hyperkalemia during CRRT predicts 90-day mortality.MedicineArticleSCOPUS10.1111/1744-9987.138042-s2.0-851246231541744998735067000