Sripusanapan A.Wareesawetsuwan N.Deepan N.Yinadsawaphan T.Qin D.Rattanawong P.Ng C.Y.Mahidol University2025-06-232025-06-232025-01-01PACE Pacing and Clinical Electrophysiology (2025)01478389https://repository.li.mahidol.ac.th/handle/20.500.14594/110871Background: Left bundle branch area pacing (LBBAP) is an emerging technique in conduction system pacing (CSP) that may offer improved outcomes over traditional methods. Typically, lumenless leads are used; however, stylet-driven leads have recently been considered. This study conducts a systematic review and meta-analysis evaluating the efficacy and complications of stylet-driven leads versus lumenless leads. Method: Databases including PubMed, Embase, and Scopus were searched from inception to June 2024 for relevant studies. We included published prospective or retrospective randomized controlled trials and cohort studies using stylet-driven leads or lumenless leads for LBBAP. Data were combined using a random-effects, generic inverse variance method of DerSimonian and Laird. Results: Sixty-eight studies involving 8996 patients from 2016 to 2023 were included. From eight head-to-head studies, the stylet-driven leads group had a comparable success rate (OR = 1.46, 95% CI: 0.89, 2.39) but showed shorter procedural time (weighted mean difference [WMD] = −16.82 min, 95% CI: −24.42, −9.21). Stylet-driven leads had a higher pacing threshold at implantation (WMD = 0.09 V, 95% CI: 0.00, 0.17) and lower lead impedance (WMD = −86.13 ohms, 95% CI: −129.46, −42.80). QRS duration and R wave amplitude were comparable initially, but at follow-up (1–12 months), stylet-driven leads had a lower R wave amplitude (WMD = −1.92 mV, 95% CI: −3.33, −0.51). Complication rates were higher with stylet-driven leads (OR = 1.80, 95% CI: 1.34, 2.41), particularly lead dislodgement (OR = 3.26, 95% CI: 1.75, 6.07) and helix damage (OR = 11.46, 95% CI: 3.58, 36.63). Conclusion: In this meta-analysis of 8996 patients, stylet-driven leads for LBBAP showed a comparable success rate to lumenless leads but was associated with a higher complication risk.MedicineArticleSCOPUS10.1111/pace.152172-s2.0-10500822654415408159