Suthat FucharoenDavid J. WeatherallThe Institute of Science and Technology for Research and Development, Mahidol UniversityWeatherall Institute of Molecular Medicine2018-06-112018-06-112012-01-01Cold Spring Harbor Perspectives in Medicine. Vol.2, No.8 (2012)215714222-s2.0-84886690091https://repository.li.mahidol.ac.th/handle/20.500.14594/13856Hemoglobin E (HbE) is an extremely common structural hemoglobin variant that occurs at high frequencies throughout many Asian countries. It is a β-hemoglobin variant, which is produced at a slightly reduced rate and hence has the phenotype of a mild form of β thalassemia. Its interactions with different forms of α thalassemia result in a wide variety of clinical disorders, whereas its coinheritance with β thalassemia, a condition called hemoglobin E β thalassemia, is by far the most common severe form of β thalassemia in Asia and, globally, comprises approximately 50% of the clinically severe β-thalassemia disorders. © 2012 Cold Spring Harbor Laboratory Press all rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1101/cshperspect.a011734