Synthesis of 4-aryltetrahydroisoquinolines: Application to the synthesis of cherylline

Somsak RuchirawatSopchok TontoolarugPoolsar SahakitpichanChulabhorn Research InstituteMahidol UniversityThe Institute of Science and Technology for Research and Development, Mahidol University2018-09-072018-09-072001-04-01Heterocycles. Vol.55, No.4 (2001), 635-640038554142-s2.0-0035307110https://repository.li.mahidol.ac.th/handle/20.500.14594/26514A concise route for the synthesis of 4-aryltetrahydroisoquinolines was developed using the addition of Grignard reagents to nitrostyrene derivatives as the key step. The application to the synthesis of cherylline was described.Mahidol UniversityChemistryPharmacology, Toxicology and PharmaceuticsSynthesis of 4-aryltetrahydroisoquinolines: Application to the synthesis of cheryllineArticleSCOPUS10.3987/COM-01-9167