Ronald GriggXinjie GaiTossapol KhamnaenShuleewan RajviroongitVisuvanathar SridharanLixin ZhangSimon CollardAnn KeepUniversity of LeedsMahidol UniversityJohnson Matthey Plc2018-06-212018-06-212005-06-01Canadian Journal of Chemistry. Vol.83, No.6-7 (2005), 990-1005000840422-s2.0-29244437147https://repository.li.mahidol.ac.th/handle/123456789/16417We herein describe a novel palladium catalysed three-component cascade process involving carbonylation of an aryl iodide to generate an acyl palladium(II) species that is intercepted by a primary aliphatic or aromatic amine, amide, or sulfonamide followed by intramolecular Michael addition to furnish N-substituted isoindolinones in good yield. Overall, the cascade results in the formation of one C-C and two C-N bonds, one ring and one stereocentre. © 2005 NRC Canada.Mahidol UniversityChemical EngineeringChemistryArticleSCOPUS10.1139/v05-111