Teerapat YingchoncharoenTeewin RakyhaoSuporn ChuncharuneePiyamitr SritaraPavit PienvichitKittiphong PaiboonsukwongPiyadon SathavorasmithKanjana SiriratThanaporn SriwantanaSirada SrihirunNathawut SibmoohFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityMahidol University2019-08-232019-08-232018-06-01Nitric Oxide - Biology and Chemistry. Vol.76, (2018), 174-17810898611108986032-s2.0-85030634045https://repository.li.mahidol.ac.th/handle/123456789/45140© 2017 Elsevier Inc. Pulmonary hypertension is a life-threatening complication in β-thalassemia. Inhaled sodium nitrite has vasodilatory effect on pulmonary vasculature. However, its effect on pulmonary artery pressure (PAP) in β-thalassemia subjects with pulmonary hypertension has never been reported. In this study, we investigated the change in PAP during inhalation of sodium nitrite in 5 β-thalassemia patients. We demonstrated that sodium nitrite administered by nebulization rapidly decreased PAP as measured by echocardiography and right heart catheterization. The effect of nitrite was short as PAP returned to baseline at end of inhalation. Our findings support acute pulmonary vasodilation effect of nitrite in β-thalassemia with pulmonary hypertension.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1016/j.niox.2017.09.010