S. SirinavinP. Suthas-Na-AynthayaMahidol University2018-10-122018-10-121985-11-01European Journal of Pediatrics. Vol.144, No.4 (1985), 395-39814321076034061992-s2.0-0022342419https://repository.li.mahidol.ac.th/handle/123456789/30856Corynebacterium diphtheriae usually produces an infection limited to the respiratory tract and the organisms rarely invade the blood stream. We report the case of a 6-year-old girl who, 2 months after an unsuccessful repair of a ventricular septal defect, developed septicaemia with nontoxigenic C. diphtheriae. The organism appeared resistant to penicillin in vitro and failed to respond to a course of trimethoprim-sulfamethoxazole to which it was susceptible in the laboratory. A cure was finally achieved using cephalothin and gentamicin, followed by an additional course of ampicillin and amoxicillin. Twelve previously recorded cases of diphtheritic sepsis and endocarditis are reviewed. © 1985 Springer-Verlag.Mahidol UniversityMedicineArticleSCOPUS10.1007/BF00441786