Precursor-directed biosynthesis of beauvericin analogs by the insect pathogenic fungus Paecilomyces tenuipes BCC 1614

Chongdee NilanontaMasahiko IsakaPrasat KittakoopSrisuda TrakulnaleamsaiMorakot TanticharoenYodhathai ThebtaranonthMahidol UniversityThailand National Center for Genetic Engineering and Biotechnology2018-07-242018-07-242002-04-22Tetrahedron. Vol.58, No.17 (2002), 3355-3360004040202-s2.0-0037156526https://repository.li.mahidol.ac.th/handle/123456789/20068Precursor-directed biosynthesis of beauvericin analogs, cyclohexadepsipeptide antibiotics, was investigated using the insect pathogenic fungus Paecilomyces tenuipes BCC 1614. Feeding L-isoleucine or D-alloisoleucine in liquid medium led to the enhanced production of beauvericin A and beauvericin B together with beauvericin and a missing analog, beauvericin C. Feeding experiments with D-isoleucine or L-alloisoleucine resulted in the production of diastereomers of beauvericins A, B and C, named allobeauvericins A, B and C, respectively. © 2002 Elsevier Science Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsPrecursor-directed biosynthesis of beauvericin analogs by the insect pathogenic fungus Paecilomyces tenuipes BCC 1614ArticleSCOPUS10.1016/S0040-4020(02)00294-6