Einapak BoontaveeyuwatNarumol Silpa-ArchaNasuda DanchaivijitrChanisada WongpraparutChulalongkorn UniversityFaculty of Medicine, Siriraj Hospital, Mahidol University2020-01-272020-01-272019-02-17Journal of Dermatological Treatment. Vol.30, No.2 (2019), 117-12214711753095466342-s2.0-85047934562https://repository.li.mahidol.ac.th/handle/123456789/51859© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Background: Even though the traditional therapy for nail psoriasis has been used for decades, no randomized, controlled trial of such treatment has been conducted to date. Objective: To evaluate the efficacy and safety of intralesional triamcinolone injections compared with 0.05% clobetasol ointment for psoriatic nails. Materials and methods: Psoriasis patients, each with three fingernails with similar degrees of severity, were randomly recruited for intralesional triamcinolone injection group, 0.05% clobetasol ointment group, and a control group. The target Nail Psoriasis Severity Index (NAPSI) score of each finger was evaluated, any adverse effects were recorded, and photographs were taken. Results: Forty-eight affected nails were analyzed. At the second month, a significantly greater reduction of the target NAPSI score was observed in the injection group compared to the control group (p =.003). There was a greatest reduction of the score in the following two month-period, which showed significant difference from the topical group (p =.003) and the control group (p = <.001). The score of the injection group, however, subsequently rose at the six-month visit so that there was no longer any statistically-significant difference between the three groups. Conclusions: In spite of its temporary effect, the intralesional triamcinolone injection is an effective and safe treatment for psoriatic nails.Mahidol UniversityMedicineArticleSCOPUS10.1080/09546634.2018.1476647