Pakamatz KhawplodYoko ShojiSukathida UbolChannarong MitmoonpitakHenry WildeAkira NishizonoIchiro KuraneKinjiro MorimotoNational Institute of Infectious DiseasesThai Red Cross AgencyNihon UniversityMahidol UniversityOita University2018-08-202018-08-202006-05-01Infection, Genetics and Evolution. Vol.6, No.3 (2006), 235-240156713482-s2.0-33645560711https://repository.li.mahidol.ac.th/handle/20.500.14594/22902The genetic diversity of the rabies virus glycoprotein (G) gene isolated from individual rabid dogs (inter-hosts) and within a single infected dog (intra-host) has been analyzed in an effort to better understand selective pressures and population shifts among rabies viruses circulating in Bangkok. Comparison of individual master sequences among inter-hosts revealed that the dog virus isolates circulating in Bangkok were phylogenetically closely related. The ectodomain of the glycoprotein was highly conserved among the virus isolates. Furthermore, the genetic diversity of the G gene within an intra-host was assessed by comparing the cloned sequences in the virus population. The comparisons revealed that rabies virus circulating in an intra-host consisted of closely related heterogenous populations with minor substitutions at nucleotide (0.19%) and amino acid levels. © 2005 Elsevier B.V. All rights reserved.Mahidol UniversityAgricultural and Biological SciencesBiochemistry, Genetics and Molecular BiologyImmunology and MicrobiologyMedicineArticleSCOPUS10.1016/j.meegid.2005.06.002