Limited polymorphism in the dihydropteroate synthetase gene (dhps) of Plasmodium vivax isolates from Thailand

Mallika ImwongSasithon PukrittayakameeQin ChengCatrin MooreSornchai LooareesuwanGeorges SnounouNicholas J. WhiteNicholas P.J. DayMahidol UniversityAustralian Army Malaria InstituteChurchill HospitalInstitut Pasteur, Paris2018-06-212018-06-212005-10-01Antimicrobial Agents and Chemotherapy. Vol.49, No.10 (2005), 4393-4395006648042-s2.0-25844506182https://repository.li.mahidol.ac.th/handle/20.500.14594/16815The dhps sequences of 55 Plasmodium vivax isolates (39 from Thailand and 16 from elsewhere) revealed mutant Pvdhps at codons 383 and/or 553 (A → G) in 33 isolates, all from Thailand. Mutations of P\dhps and P\dhfr were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrimethamine resistance. Copyright © 2005, American Society for Microbiology. All Rights Reserved.Mahidol UniversityMedicinePharmacology, Toxicology and PharmaceuticsLimited polymorphism in the dihydropteroate synthetase gene (dhps) of Plasmodium vivax isolates from ThailandArticleSCOPUS10.1128/AAC.49.10.4393-4395.2005