A rare association of α0-thalassemia (--SEA) and an initiation codon mutation (ATG→A-G) of the α2 gene causes Hb H disease in Thailand

Vip ViprakasitWorrawut ChinchangWaraporn GlomglaoVoravarn S. TanphaichitrMahidol University2018-06-212018-06-212005-08-16Hemoglobin. Vol.29, No.3 (2005), 235-240036302692-s2.0-23244456639https://repository.li.mahidol.ac.th/handle/20.500.14594/16305Several rare and hitherto unidentified non deletional α-thalassemias (αTα or ααT) have been reported from Thailand within the past few years. Interactions of these determinants with α0-thalassemia (thal) (--/), which is highly prevalent in this region, give rise to various genotypes (--/ αTα or --/ααT) underlying Hb H disease. We report herein the interaction of a rare initiation codon mutation of the α2 gene and α0-thal in a Thal boy with Hb H disease. This finding highlights a wide variety of molecular pathology of the α-globin genes underlying α-thal syndrome in Southeast Asia. Copyright © 2005 Taylor & Francis, Inc.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineA rare association of α0-thalassemia (--SEA) and an initiation codon mutation (ATG→A-G) of the α2 gene causes Hb H disease in ThailandArticleSCOPUS10.1081/HEM-200066339