Nicholas J. WhiteMahidol UniversityChurchill Hospital2018-12-112019-03-142018-12-112019-03-142016-12-01Trends in Parasitology. Vol.32, No.12 (2016), 918-92014715007147149222-s2.0-84997281847https://repository.li.mahidol.ac.th/handle/20.500.14594/40784© 2016 The Author Relapse may have evolved in malaria as a mechanism to avoid suppression by more virulent species in mixed infections, thereby increasing transmission opportunities. Later evolution of long latency in Plasmodium vivax was a necessary adaptation as early hominins moved to colder areas with shorter mosquito breeding seasons. Genetic diversity was maintained through heterologous hypnozoite activation.Mahidol UniversityImmunology and MicrobiologyMedicineShort SurveySCOPUS10.1016/j.pt.2016.08.014