Ricardo AguasRichard J. MaudeM. Gabriela M. GomesLisa J. WhiteNicholas J. WhiteArjen M. DondorpHarvard School of Public HealthUniversidade do Porto, Centro de Investigação em Biodiversidade e Recursos GenéticosUniversity of OxfordLiverpool School of Tropical MedicineMahidol University2019-08-282019-08-282018-07-02Clinical Infectious Diseases. Vol.67, No.2 (2018), 295-30215376591105848382-s2.0-85051251703https://repository.li.mahidol.ac.th/handle/20.500.14594/46519© The Author(s) 2018. Assessing the importance of targeting the chronic Plasmodium falciparum malaria reservoir is pivotal as the world moves toward malaria eradication. Through the lens of a mathematical model, we show how, for a given malaria prevalence, the relative infectivity of chronic individuals determines what intervention tools are predicted be the most effective. Crucially, in a large part of the parameter space where elimination is theoretically possible, it can be achieved solely through improved case management. However, there are a significant number of settings where malaria elimination requires not only good vector control but also a mass drug administration campaign. Quantifying the relative infectiousness of chronic malaria across a range of epidemiological settings would provide essential information for the design of effective malaria elimination strategies. Given the difficulties obtaining this information, we also provide a set of epidemiological metrics that can be used to guide policy in the absence of such data.Mahidol UniversityMedicineArticleSCOPUS10.1093/cid/ciy055