Suttipun SungsuwanNopporn RuangsupapichartSamran PrabpaiPalangpon KongsaereeTienthong ThongpanchangMahidol UniversityThailand National Center for Genetic Engineering and Biotechnology2018-09-242018-09-242010-01-01Tetrahedron Letters. Vol.51, No.38 (2010), 4965-4967004040392-s2.0-78549253787https://repository.li.mahidol.ac.th/handle/20.500.14594/28821A new chiral derivatizing agent, tetrahydro-1,4-epoxynaphthalene-1- carboxylic acid (THENA), with a represented syn-periplanar disposition of O-Ca-CαO as a part of the bicyclic system to lock the aromatic residue conformation and the availability of an internal reference proton for 1H NMR spectral alignment, is introduced. In the determination of the absolute configuration of chiral secondary alcohols, THENA offered good uniformity of Δδ with high reliability, resulting in unambiguous assignment of the absolute configuration. © 2010 Elsevier Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.tetlet.2010.07.062