Sasithon PukrittayakameeMallika ImwongPratap SinghasivanonKasia StepniewskaNicholas J. DayNicholas J. WhiteMahidol University2018-07-122018-07-122008-09-01American Journal of Tropical Medicine and Hygiene. Vol.79, No.3 (2008), 378-384000296372-s2.0-51949096026https://repository.li.mahidol.ac.th/handle/20.500.14594/19291The gametocytocidal and asexual stage activities of eight antimalarial and eight antibiotic-containing regimens were evaluated in 349 adult patients with P. vivax malaria. Gametocytemia was found in 63% of patients (22% before and 41% after treatment). The median (range) gametocyte clearance time was 24 hours (range, 2-504 hours) and correlated with asexual parasite clearance time (r = 0.52, P < 0.001). Gametocytemia in vivax malaria was more common in patients with admission parasitemia > 10,000/μL and after treatment with drugs which have weak antimalarial activity, and was also associated with an increased rate of vivax reappearance (29.4% versus 14.1%, P = 0.002). Sexual stage activities corresponded with asexual stage activity for all tested regimens. Treatment with potent antimalarial drugs reduces the transmission potential of P. vivax. Copyright © 2008 by The American Society of Tropical Medicine and Hygiene.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS