Nisachon KhunnawutmanothamNitirat ChimnoiPatchareenart SaparpakornPornpan PungpoSuda LouisirirotchanakulSupa HannongbuaSupanna TechasakulChulabhorn Research InstituteKasetsart UniversityUbon Rajathanee UniversityMahidol University2018-08-242018-08-242007-02-01Molecules. Vol.12, No.2 (2007), 218-230142030492-s2.0-33847728258https://repository.li.mahidol.ac.th/handle/20.500.14594/24372Based on the molecular modeling analysis against Y181C HIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactam nitrogen and 2-chloro-8-arylthiomethyl were synthesized via an efficient route. Some of them were evaluated for their antiviral activity against HIV-1 RT subtype E and were found to exhibit virustatic activity comparable to some clinically used therapeutic agents. © 2007 by MDPI.Mahidol UniversityChemistryArticleSCOPUS10.3390/12020218