Weerachai SrivanichakornIan F. GodslandHazel ThomsonShivani MisraPochamana PhisalprapaPhunchai CharatcharoenwitthayaPornpoj PramyothinChaiwat WashirasaksiriChamukuttan SnehalathaAmbady RamachandranK. George M.M. AlbertiDesmond G. JohnstonNick S. OliverImperial College LondonMahidol UniversityDr. A Ramachandran's Diabetes Hospitals2018-12-212019-03-142018-12-212019-03-142017-12-01Diabetes Research and Clinical Practice. Vol.134, (2017), 183-19018728227016882272-s2.0-85032990287https://repository.li.mahidol.ac.th/handle/20.500.14594/41697© 2017 Elsevier B.V. Aims Variation in cardiometabolic risk in prediabetes and any impacts of ethnicity on such variation have been little studied. In an ethnically diverse dataset, selected according to a high-risk HbA1c-based definition of prediabetes, we have investigated relationships between glycaemia and cardiometabolic risk factors and the influence of ethnicity on these relationships. Methods We undertook a cross-sectional analysis of baseline data from a diabetes prevention study in the UK and a chronic care clinic in Thailand, selected for people without diabetes (fasting plasma glucose <7.0 mmol/l) with HbA1c 6.0–6.4% (42–47 mmol/mol). Thai (n = 158) and UK White (n = 600), South Asian (n = 112), Black (n = 70) and other/mixed (n = 103) groups were distinguished and measurements included fasting plasma glucose (FPG), blood pressure (BP), lipids and insulin resistance-related risk factors (IRFs). Results Independently of individual characteristics including ethnicity, only systolic BP was weakly associated with FPG (beta coefficient 1.76 (95%CI 0.10–3.42), p 0.03) and only LDL-c with IFG (FPG 5.6 to <7) (adjusted −0.14 (−0.27, −0.003) p 0.04). There were no significant independent associations with cardiometabolic risk factors when categories of impaired fasting glucose (FPG ≥ 6.1 to <7.0 mmol/L) were considered. Relative to White, South Asian ethnicity was independently associated with lower systolic and diastolic BP, Black with lower triglycerides, cholesterol/HDL-c ratio and having 2 or more IRFs, and Thai with lower cholesterol/HDL-c ratio and all three non-white ethnicities with lower total and LDL cholesterol. Conclusion In high-risk HbA1c-defined prediabetes additional measurement of FPG will add little to evaluation of cardiometabolic risk. Additionally, UK Whites tend to have the most adverse cardiometabolic profile of any ethnic group.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1016/j.diabres.2017.10.017