Netiya KaraketKanyaratt SupaibulwatanaSupatsara OunsukValérie Bultel-PoncéVan Cuong PhamBernard BodoMahidol UniversityMuseum National d'Histoire NaturelleInstitut des Biomolecules Max MousseronVietnamese Academy of Science and Technology Institute of Chemistry2018-06-112018-06-112012-05-14Natural Product Communications. Vol.7, No.2 (2012), 169-170155594751934578X2-s2.0-84859981938https://repository.li.mahidol.ac.th/handle/20.500.14594/13457Bioassay-guided fractionation of the MeOH extract from the stem bark of Neonauclea purpurea used in traditional medicine, resulted in the isolation of 2 indole alkaloids, cadambine (1) and α-dihydrocadambine (2), as well as a quinolic compound, 2,6-dimethoxy-1,4-benzoquinone (3). Antimalarial activity evaluation showed that compounds 2 and 3 exhibited mild in vitro antimalarial activity against Plasmodium falciparum, the chloroquine-resistant strain K1 with IC 50 values of 6.6 and 11.3 μM, respectively. Compounds 1 and 2 showed no cytotoxicity to monkey (Vero) cells, but compound 3 showed weak cytotoxicity with an IC 50 value of 1.19 μM.Mahidol UniversityAgricultural and Biological SciencesMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS