Maneekarn ChinworrungseePrasat KittakoopMasahiko IsakaAmporn RungrodMorakot TanticharoenYodhathai ThebtaranonthMahidol UniversityThailand National Center for Genetic Engineering and Biotechnology2018-09-072018-09-072001-08-06Bioorganic and Medicinal Chemistry Letters. Vol.11, No.15 (2001), 1965-19690960894X2-s2.0-0035817392https://repository.li.mahidol.ac.th/handle/20.500.14594/26454Three known compounds, 2-hexylidene-3-methylsuccinic acid (1), cytochalasin Q (2), and 5-carboxymellein (3), together with two new derivatives, 2-hexylidene-3-methylsuccinic acid 4-methyl ester (4) and an ophiobolane sesterterpene named halorosellinic acid (5), were isolated from culture broth of the marine fungus Halorosellinia oceanica BCC 5149. Compounds 1-3 exhibited moderate cytotoxicity against KB and BC-1 cell lines with IC50values of 1-13 μg/mL, while compounds 2, 3, 5, and 6 showed antimalarial activity with respective IC50values of 17, 4, 13, and 19 μg/mL. Halorosellinic acid (5) possessed only weak antimycobacterial activity with the minimum inhibitory concentration of 200 μg/mL. © 2001 Elsevier Science Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/S0960-894X(01)00327-4