Phasuk A.Putthabucha N.Winuprasith T.Srisawat N.Khomein P.Mahidol University2025-10-162025-10-162025-10-08Journal of Materials Chemistry B Vol.13 No.39 (2025) , 12614-126232050750Xhttps://repository.li.mahidol.ac.th/handle/123456789/112619The renewed interest in hemoperfusion for extracorporeal blood purification has spurred extensive research into the development of new potential adsorbents. In this study, the potential of polymethyl methacrylate (PMMA) as a hemoperfusion adsorbent was explored. An approach to prepare a suitable adsorbent from PMMA was developed. Porous PMMA microspheres with a size over 300 μm and a high specific surface area were prepared with the ability to tune their pore structure by changing the porogen concentration. Hemocompatibility was thoroughly evaluated to assess their suitability for direct blood-contact hemoperfusion applications. The newly developed porous PMMA microspheres demonstrated effective removal of representative cytokines (MCP-1 and IL-6) with different molecular weights and net charges at physiological pH, achieving approximately 80% removal efficiency. These results highlight their strong potential as hemoperfusion adsorbents.Materials ScienceChemistryMedicineEngineeringArticleSCOPUS10.1039/d5tb01570g2-s2.0-10501803496620507518