Porntep ChomcheonSuthep WiyakruttaNongluksna SriubolmasNattaya NgamrojanavanichChulabhorn MahidolSomsak RuchirawatPrasat KittakoopChulabhorn Research InstituteChulalongkorn UniversityMahidol UniversityThe Institute of Science and Technology for Research and Development, Mahidol University2018-09-132018-09-132009-01-01Phytochemistry. Vol.70, No.1 (2009), 121-127003194222-s2.0-59049083596https://repository.li.mahidol.ac.th/handle/20.500.14594/27077The endophytic mitosporic Dothideomycete sp. LRUB20 was found to produce pyrone derivatives, dothideopyrones A-D (1, 3, 4, and 5), together with seven known compounds, including questin (9), asterric acid (10), methyl asterrate (11), sulochrin (12), and eugenitin (13), 6-hydroxymethyleugenitin (14), and cis, trans-muconic acid (15). Dothideopyrone D (5) and its acetate derivative 6 exhibited moderate cytotoxic activity. This is the first report on a naturally occurring muconic acid, which is commonly known as a biomarker in environments after exposure to benzene and phenol (or derivatives). Interestingly, the LRUB20 fungus could produce muconic acid in relatively high yield (47.8 mg/L). The utility of endophytic fungi in the field of white biotechnology is discussed. © 2008 Elsevier Ltd. All rights reserved.Mahidol UniversityAgricultural and Biological SciencesBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1016/j.phytochem.2008.10.007