Thomas WeitzelSabine DittrichJavier LópezWeerawat PhukliaConstanza Martinez-ValdebenitoKatia VelásquezStuart D. BlacksellDaniel H. ParisKatia AbarcaUniversidad del DesarrolloPontificia Universidad Católica de ChileHospital de AncudLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU)Nuffield Department of Clinical MedicineMahidol University2018-12-112019-03-142018-12-112019-03-142016-09-08New England Journal of Medicine. Vol.375, No.10 (2016), 954-96115334406002847932-s2.0-84986588542https://repository.li.mahidol.ac.th/handle/20.500.14594/41135Copyright © 2016 Massachusetts Medical Society. Scrub typhus is a life-threatening zoonosis caused by Orientia tsutsugamushi organisms that are transmitted by the larvae of trombiculid mites. Endemic scrub typhus was originally thought to be confined to the so called "tsutsugamushi triangle" within the Asia-Pacific region. In 2006, however, two individual cases were detected in the Middle East and South America, which suggested that the pathogen was present farther afield. Here, we report three autochthonous cases of scrub typhus caused by O. tsutsugamushi acquired on Chiloé Island in southern Chile, which suggests the existence of an endemic focus in South America.Mahidol UniversityMedicineArticleSCOPUS10.1056/NEJMoa1603657