C. MartinF. GimenezK. N. BangchangJ. KarbwangR. FarinottiI. W. WainerHopital Pitie SalpetriereMahidol UniversityUniversite Paris-Sud XIMcGill University2018-02-272018-02-271994-08-01European Journal of Clinical Pharmacology. Vol.47, No.1 (1994), 85-8714321041003169702-s2.0-0028026661https://repository.li.mahidol.ac.th/handle/20.500.14594/9659We studied the pharmacokinetics of the enantiomers of mefloquine in whole blood in healthy Thai volunteers after administration of a single oral dose of 750 mg of the racemic mixture. Mefloquine pharmacokinetics were stereoselective. The peak concentrations and areas under the curve of the (-) enantiomer were significantly higher than those of its antipode (0.79 versus 0.46 μg · ml -1 and 402 versus 94 μg · h · ml -1 ). The half-lives of (-)MQ were significantly longer than those of (+)MQ (531 versus 206 h). No stereoselectivity was observed for t max values. © 1994 Springer-Verlag.Mahidol UniversityMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1007/BF00193485