Vilasinee HirunpanichAnocha UtaipatNoppawan Phumala MoralesNantavan BunyapraphatsaraSato, HitoshiAngkana HerunsaleeChuthamanee Suthisisangวิลาสินี หิรัญพานิชอโนชา อุทัยพัฒน์นันทวัน บุณยะประภัศรจุฑามณี สุทธิสีสังข์Mahidol University. Faculty of Pharmacy. Department of Pharmacology.Mahidol University. Faculty of Pharmacy. Department of PharmacognosyMahidol University. Facutly of Science. Department of Pharmacology2010-08-052011-08-292017-11-062010-08-052011-08-292017-11-062010-08-052005Biological and Pharmaceutical Bulletin. Vol.28, No.3 (2005), 481-40918-6158https://repository.li.mahidol.ac.th/handle/123456789/3062The present study quantitatively investigated the antioxidant effects of the aqueous extracts from dried calyx of Hibiscus sabdariffa LINN. (roselle) in vitro using rat low-density lipoprotein (LDL). Formations of the conjugated dienes and thiobarbituric acid reactive substances (TBARs) were monitored as markers of the early and later stages of the oxidation of LDL, respectively. Thus, we demonstrated that the dried calyx extracts of roselle exhibits strong antioxidant activity in Cu2+ -mediated oxidation of LDL (p<0.05) in vitro. The inhibitory effect of the extracts on LDL oxidation was dose-dependent at concentrations ranging from 0.1 to 5 mg/ml. Moreover, 5 mg/ml of roselle inhibited TBARs-formation with greater potency than 100 mrgM of vitamin E. In conclusion, this study provides a quantitative insight into the potent antioxidant effect of roselle in vitro.366 kbapplication/pdfengMahidol UniversityHibiscus sabdariffaRoselleLow-density Lipoprotein(LDL) OxidationAntioxidantsResearch ArticlePharmaceutical Society of Japan