Jialun ZhouJulian ElliottPatrick C.K. LiPoh Lian LimSasisopin KiertiburanakulNagalingeswaran KumarasamyTuti Parwati MeratiSanjay PujariYi Ming A. ChenPraphan PhanuphakSaphonn VonthanakThira SirisanthanaSomnuek SungkanuparphChristopher K.C. LeeAdeeba KamarulzamanShinichi OkaFujie ZhangGoa TauRossana DitangcoKirby InstituteQueen Elizabeth Hospital Hong KongTan Tock Seng HospitalMahidol UniversityYR Gaitonde Centre for AIDS Research and EducationUniversitas UdayanaInstitute of Infectious DiseasesNational Yang-Ming University TaiwanThe HIV Netherlands Australia Thailand Research CollaborationNational Center for HIV/AIDSResearch Institute for Health SciencesHospital Sungai BulohUniversity of MalayaNational Center for Global Health and MedicineBeijing Ditan HospitalPort Moresby General HospitalGokila2018-09-132018-09-132009-04-21BMC Infectious Diseases. Vol.9, (2009)147123342-s2.0-65649133108https://repository.li.mahidol.ac.th/handle/123456789/28114Background: To assess the risk and the prognostic significance of tuberculosis (TB) diagnosis in patients from The TREAT Asia HIV Observational Database, a multi-centre prospective cohort of HIV-infected patients receiving HIV care in the Asia-Pacific region. Methods: The risk of TB diagnosis after recruitment was assessed in patients with prospective follow-up. TB diagnosis was fitted as a time-dependent variable in assessing overall survival. Results: At baseline, 22% of patients were diagnosed with TB. TB incidence was 1.98 per 100 person-years during follow up, with predictors including younger age, lower recent CD4 count, duration of antiretroviral treatment, and living in high TB burden countries. Among 3279 patients during 6968 person-years, 142 died (2.04 per 100 person-years). Compared to patients with CDC category A or B illness only, mortality was marginally higher in patients with single Non-TB AIDS defining illness (ADI), or TB only (adjusted HR 1.35, p = 0.173) and highest in patients with multiple non-TB AIDS or both TB and other ADI (adjusted HR 2.21, p < 0.001). Conclusion: The risk of TB diagnosis was associated with increasing immunodeficiency and partly reduced by antiretroviral treatment. The prognosis of developing TB appeared to be similar to that following a diagnosis of other non-TB ADI. © 2009 Zhou et al; licensee BioMed Central Ltd.Mahidol UniversityMedicineArticleSCOPUS10.1186/1471-2334-9-46