Facile syntheses of 3-halo and mixed 3,5-dihalo analogues of N-acetye-L-tyrosine via sulfonic acid-catalysed regioselective monohalogenation.

Pakorn BovonsombatKhanthapura, P.Krause, M.M.Leykajarakul, J.Mahidol University International College, Science Division.2015-06-182018-03-082015-06-182018-03-0820152008Tetrahedron Letters. Vol. 49, No. 49 (2008), 7008-7011https://repository.li.mahidol.ac.th/handle/123456789/9961The combination of catalytic amounts of p-toluenesulfonic acid and 1 equiv of N-halosuccinimide afforded highly selective ring-halogenation of N-acetyl-L-tyrosine, furnishing either N-acetyl-3-halo-L-tyrosine analogues or mixed 3,5-dihalo derivatives in a one-pot reaction with excellent yields at room temperature.engMahidol Universityp-toluenesulfonic acid,N-halosuccinimideN-acetyl-LtyrosineFacile syntheses of 3-halo and mixed 3,5-dihalo analogues of N-acetye-L-tyrosine via sulfonic acid-catalysed regioselective monohalogenation.Article