Charuwan DaengrotVatcharin RukachaisirikulChittreeya TansakulTienthong ThongpanchangSouwalak PhongpaichitKawitsara BowornwiriyapanJariya SakayarojPrince of Songkla UniversityMahidol UniversityThailand National Center for Genetic Engineering and Biotechnology2018-11-232018-11-232015-04-24Journal of Natural Products. Vol.78, No.4 (2015), 615-62215206025016338642-s2.0-84928819084https://repository.li.mahidol.ac.th/handle/20.500.14594/35465© 2015 The American Chemical Society and American Society of Pharmacognosy. Four new compounds including two eremophilane sesquiterpenes, penicilleremophilanes A (1) and B (2), as well as two sulfur-containing biphenols, penicillithiophenols A (3) and B (4), were isolated from the soil fungus Penicillium copticola PSU-RSPG138 together with 16 known compounds. Their structures were elucidated by spectroscopic methods. Known sporogen AO-1 exhibited significant antimalarial activity against Plasmodium falciparum with an IC<inf>50</inf> value of 1.53 μM and cytotoxic activity to noncancerous (Vero) cell lines with an IC<inf>50</inf> value of 4.23 μM. Although compound 1 was approximately half as active against P. falciparum with the IC<inf>50</inf> value of 3.45 μM, it showed much weaker cytotoxic activity.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicineArticleSCOPUS10.1021/np5005328