Maneekarn ChinworrungseeSuthep WiyakruttaNongluksna SriubolmasPhitaya ChuailuaApichart SuksamrarnSrinakharinwirot UniversityMahidol UniversityChulalongkorn UniversityRamkhamhaeng University2018-07-122018-07-122008-05-01Archives of Pharmacal Research. Vol.31, No.5 (2008), 611-61619763786025362692-s2.0-43749109407https://repository.li.mahidol.ac.th/handle/20.500.14594/18934Bioassay-guided fractionation of the extract of the endophytic fungus KLAR 5 belonging to order Hypocreales, which was isolated from the twig of Knema laurina (Blume) Warb., resulted in the isolation of brefeldin A (1), 8-deoxy-trichothecin (2), trichothecolone (3), 7α-hydroxytrichodermol (4), and 7α-hydroxyscirpene (5). Compound 5 was isolated from natural source for the first time. Compound 1 was very highly active against human epidermoid carcinoma of the mouth, human breast cancer (BC-1), and human small cell lung cancer (NCI-H187) cells whereas compounds 2 and 4 were selectively active against BC-1 and NCI-H187 cells. Compounds 3 and 5 were moderately active against these three cancer cell lines. © 2008 The Pharmaceutical Society of Korea.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1007/s12272-001-1201-x