Puminun PunthaseeAvassaya VanitchaSumrit WacharasindhuMahidol University2018-09-242018-09-242010-03-31Tetrahedron Letters. Vol.51, No.13 (2010), 1713-1716004040392-s2.0-76949103156https://repository.li.mahidol.ac.th/handle/20.500.14594/28750A new approach to synthesize 3-alkylquinazolin-4-ones is developed. Treatment of quinazolin-4-ones with Mukaiyama's reagent, a base and a primary amine nucleophile results in the formation of 3-alkylquinazolin-4-ones in moderate to good yields under mild conditions. Using this methodology, a one-step synthesis of the natural alkaloid, echinozolinone, is accomplished. © 2010 Elsevier Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.tetlet.2010.01.087