J. KarbwangK. Na BangchangD. J. BackD. BunnagMahidol UniversityUniversity of Liverpool2018-08-102018-08-101991-06-01European Journal of Clinical Pharmacology. Vol.40, No.6 (1991), 631-63314321041003169702-s2.0-0025758449https://repository.li.mahidol.ac.th/handle/20.500.14594/22141The kinetics of a single oral dose of mefloquine given either alone or with ampicillin has been studied in 8 healthy Thai male volunteers. There was a significantly higher maximum whole blood mefloquine concentration after coadministration with ampicillin (1648 vs 1228 ng·ml-1), as well as a significantly reduced terminal half life (15.3 vs 17.7 days), mean residence time (20.1 vs 23.4 days) and volume of distribution at steady state (14.1 vs 19.4 l·kg-1). Although there was no significant change in the AUC from zero time to infinity, the AUC from zero time to 5 days was significantly increased by ampicillin (4.86 vs 3.27 μg·ml-1 day). These changes in mefloquine disposition after antibiotic treatment may be due both to an increase in fractional bioavailability and a reduction in the enterohepatic recycling of mefloquine. © 1991 Springer-verlag.Mahidol UniversityMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1007/BF00279985