Gloria L. SilvaRoberto R. GilBaoliang CuiHeebyung ChaiThawatchai SantisukEkarath SrisookVichai ReutrakulPatoomratana TuchindaSmaisukh SophasanSuparp SujaritSuchart UpathamSean M. LynnJohn E. FarthingShi Lin YangJane A. LewisMelanie J. O'NeillNorman R. FarnsworthGeoffrey A. CordellJohn M. PezzutoA. Douglas KinghornUniversity of Illinois at ChicagoThe Forest Herbarium, Thailand Ministry of Natural Resources and EnvironmentMahidol UniversityGlaxoSmithKline2018-07-042018-07-041997-01-13Tetrahedron. Vol.53, No.2 (1997), 529-538004040202-s2.0-0031013412https://repository.li.mahidol.ac.th/handle/20.500.14594/17905Coronalolide methyl ester (1), coronalolide (2), and coronalolic acid (3) were isolated from the leaves and/or stems of Gardenia coronaria. A further compound, methyl coronalolate acetate (4), was purified from the stems after methylation. The novel compounds 1-4 have the rare ring-A seco-cycloartane carbon skeleton and their structures were assigned on the basis of spectral data and molecular modeling, as well as X-ray crystallography performed on 1. Compounds 1 and 2 were also isolated from the leaves of Gardenia sootepensis and showed broad cytotoxic activity when evaluated against a panel of human cancer cell lines.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/S0040-4020(96)01003-4