Jakapun SoponpongKulvadee DolsophonChawanee ThongpanchangAnthony LindenTienthong ThongpanchangMahidol UniversityUniversity of ZurichThailand National Center for Genetic Engineering and BiotechnologySrinakharinwirot University2020-01-272020-01-272019-02-07Tetrahedron Letters. Vol.60, No.6 (2019), 497-50018733581004040392-s2.0-85059805363https://repository.li.mahidol.ac.th/handle/20.500.14594/50259© 2019 Elsevier Ltd The structure of a constrained bicyclic chiral derivatizing agent (CDA), 1,2,3,4-tetrahydro-1,4-epoxynaphthalene-1-carboxylic acid, THENA 1, was modified by replacing both exo-methylene protons with deuterium atoms. The modified CDA, THENA-d 2 2, could be used to assign the absolute configuration of chiral secondary alcohols with good reliability. Compared with THENA, the multiplicity of the methylene proton signals in the 1 H NMR spectra of THENA-d 2 derivatives is less complicated and the new CDA thus offers simpler NMR spectra for data interpretation.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryArticleSCOPUS10.1016/j.tetlet.2019.01.013