Danpanichkul P.Duangsonk K.Uawithya E.Kongarin S.Simadibrata D.M.Polpichai N.Suenghataiphorn T.Wattanachayakul P.Pang Y.Sukphutanan B.Kaewdech A.Panpradist N.Chaiyakunapruk N.Pupaibool J.Wijarnpreecha K.Mahidol University2024-07-202024-07-202024-07-01Journal of Clinical Medicine Vol.13 No.13 (2024)https://repository.li.mahidol.ac.th/handle/20.500.14594/99734Background/Objective: Clostridioides difficile infection (CDI) is a common healthcare-associated ailment, presenting major health and economic challenges, especially for the elderly. Despite its prevalence, comprehensive data about CDI’s impact on the elderly are limited. Methods: This study used the Global Burden of Disease Study 2019 data to analyze CDI trends from 2000 to 2019, considering factors like sex, region, and sociodemographic index (SDI). Results: This study revealed that CDI caused approximately 18,181 deaths and 252,709 disability-adjusted life years (DALYs) among the elderly worldwide. The Americas showed the highest CDI burden, while the Eastern Mediterranean saw the steepest rate increase from 2000 to 2019. Regions with a high SDI also displayed substantial CDI impact. Conclusions: The escalating burden of CDI in the elderly, especially in high-SDI areas and the Americas, emphasizes an urgent need for targeted public health strategies.MedicineArticleSCOPUS10.3390/jcm131337402-s2.0-8519845123120770383