Sakchai HongthongChutima KuhakarnVichai ReutrakulSurawat JariyawatPawinee PiyachaturawatNarong NuntasaenThaworn JaipetchMahidol UniversityNational Park, Wildlife and Plant Conservation Department, Thailand2018-11-092018-11-092014-01-01Natural Product Communications. Vol.9, No.7 (2014), 929-932155594751934578X2-s2.0-84905110963https://repository.li.mahidol.ac.th/handle/20.500.14594/33151Bioassay-guided fractionation of the cytotoxic ethyl acetate fraction of the sequential methanol extract from the leaves and twigs of Dasymaschalon sootepense led to the isolation of a new 7-hydroxy aporphine alkaloid, 6a,7-dehydrodasymachaline (1) along with the five known compounds (-)-nordicentrine (2), dicentrinone (3), (-)-sinactine (4), aristolactam AII (5) and epiberberine (6). Their structures were elucidated by spectroscopic methods. This is the first report of alkaloids 1-2 and 5-6 from the genus Dasymaschalon. Compounds 1 and 5 showed cytotoxicity against a panel of cancer cell lines.Mahidol UniversityAgricultural and Biological SciencesMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS