Calvin Jianyi KohSundeep LakhtakiaMitsuhiro KidaCosmas Rinaldi A. LesmanaTiing Leong AngCharles Kieng Fong VuThan Than AyeSun Hwa ParkMajid A. AlmadiCharing Ching Ning ChongRaymond Shing Yan TangXi WuIda HilmiVinay DhirNonthalee PausawasdiJahangeer BashaZhen Dong JinAi Ming YangAnthony Yuen Bun TeohDong Wan SeoHsiu Po WangKhek Yu HoSiriraj HospitalChinese Academy of Medical Sciences & Peking Union Medical CollegeChinese University of Hong Kong, Faculty of MedicineNational Taiwan University HospitalKing Khalid University HospitalNational University HospitalUniversiti MalayaNUS Yong Loo Lin School of MedicineSecond Military Medical UniversityPrince of Wales Hospital Hong KongKitasato University HospitalAsian Institute of Gastroenterology IndiaChangi General HospitalUniversity of Ulsan College of MedicineTan Tock Seng HospitalSanpya General HospitalGlobal HospitalsMedistra Hospital2022-08-042022-08-042021-06-01Endoscopy. Vol.53, No.6 (2021), 595-602143888120013726X2-s2.0-85092690649https://repository.li.mahidol.ac.th/handle/123456789/78192Background Although endoscopic ultrasound (EUS) features and criteria have been described in chronic pancreatitis, challenges remain with interoperator variability and ease of adoption. The aim of this study was to define and validate the EUS features of chronic pancreatitis in a multicenter prospective study in Asia. Method: The study was divided into two parts: the first part was conducted to derive the EUS features of chronic pancreatitis with adequate interoperator agreement; the second was to prospectively evaluate these features in a multicenter cross-sectional study and determine the optimal combination of features for the diagnosis of chronic pancreatitis. Prospectively enrolled cases had standard internationally validated radiologic or histologic features of chronic pancreatitis, and controls were patients without chronic pancreatitis who underwent EUS examination. Results: The top six EUS features that had good interobserver agreement (mean kappa 0.73, range 0.60-0.90) were selected to be further evaluated in part II of the study. These included: hyperechoic foci with shadowing, lobularity with honeycombing, cysts, dilated main pancreatic duct, dilated side branches, and calculi in the main pancreatic duct. A total of 284 subjects (132 cases, 152 controls) were enrolled from 12 centers in Asia. All six features had high accuracy ranging from 63.3% to 89.1%. Two or more of these six EUS features accurately defined chronic pancreatitis (sensitivity 94.7%, specificity 98.0%), with an area under the receiver operating curve of 0.986. Conclusion: This multicenter Asian study characterized and defined the EUS features of chronic pancreatitis. This provides a useful tool in clinical practice and further research in pancreatic cancer surveillance.Mahidol UniversityMedicineArticleSCOPUS10.1055/a-1217-3112