V. UahkowithchaiR. TechasoponmaniS. SirisinhaMahidol University2018-03-222018-03-221977-12-01Southeast Asian Journal of Tropical Medicine and Public Health. Vol.8, No.4 (1977), 486-493003836192-s2.0-0017572769https://repository.li.mahidol.ac.th/handle/123456789/10283Immunization of rats with excretions and secretions from an in vitro culture fluid (ES antigens) of adult female Angiostrongylus cantonensis markedly enhanced their resistance to infection by third-stage larvae. Mortality rate, survival period, worm development and worm recovery, determined after a lethal challenge with infective larvae, were compared in immunized and unimmunized animals. Wit regard to those criteria, the results obtainted with animals that had been immunized with ES antigens from adult males were found to be indistinguishable from those of the unimmunized controls. On the contrary, those immunized with ES antigens from adult females had lower mortality rate, increased survival period, and lower worm burden. Both male and female worms recovered from brain and mature adults recovered from pulmonary arteries of rats that had been immunized with female ES antigens were also found to be stunted.Mahidol UniversityMedicineArticleSCOPUS