Leonardo L.Kenangalem E.Poespoprodjo J.R.Noviyanti R.Price R.N.Anstey N.M.Minigo G.Kho S.Mahidol University2023-06-182023-06-182022-12-01Malaria Journal Vol.21 No.1 (2022)https://repository.li.mahidol.ac.th/handle/123456789/84850Background: Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria. Methods: Using flow-cytometry, circulating polymorphonuclear-MDSC were evaluated in cryopreserved samples from patients with uncomplicated Plasmodium vivax (n = 8) and uncomplicated (n = 4) and severe (n = 16) falciparum malaria from Papua, Indonesia. Results: The absolute number of circulating polymorphonuclear-MDSC were significantly elevated in severe falciparum malaria patients compared to controls (n = 10). Polymorphonuclear-MDSC levels in uncomplicated vivax malaria were also elevated to levels comparable to that seen in severe falciparum malaria. Conclusion: Control of expansion of immunosuppressive MDSC may be important for development of effective immune responses in falciparum and vivax malaria.Immunology and MicrobiologyArticleSCOPUS10.1186/s12936-022-04268-62-s2.0-851373150131475287536068577