Panarat CharoenchaiSrunya VajrodayaWinai SomprasongChulabhorn MahidolSomsak RuchirawatPrasat KittakoopChulabhorn Research InstituteKasetsart UniversityThailand Ministry of Agriculture and CooperativesChulabhorn Graduate InstituteMahidol University2018-09-242018-09-242010-11-22Planta Medica. Vol.76, No.16 (2010), 1940-194314390221003209432-s2.0-78349248668https://repository.li.mahidol.ac.th/handle/123456789/28594Crude extracts (CH2Cl2 and MeOH) of 20 plants in the family Acanthaceae were screened for their antiplasmodial, cytotoxic, antioxidant, and radical scavenging activities. These plants included Asystasia nemorum, Barleria cristata, B. strigosa, Dicliptera burmanni, Eranthemum tetragonum, Hygrophila ringens, Justicia balansae, J. procumbens, Lepidagathis incurva, Peristrophe lanceolaria, Phaulopsis dorsiflora, Ruellia kerrii, Strobilanthes auriculata, S. corrugata, S. cusia, S. dimorphotricha, S. karensium, S. maxwellii, S. pateriformis, and S. brandisii. CH 2Cl2 extracts of A. nemorum, S. corrugata, S. cusia, S. maxwellii, S. pateriformis, and S. brandisii, as well as MeOH extracts of J. balansae and J. procumbens, showed antiplasmodial activity with IC50 values of 10100μg/mL. CH2Cl2 extracts of nine plants including D. burmanni, H. ringens, J. balansae, J. procumbens, L. incurva, P. lanceolaria, P. dorsiflora, S. corrugata, and S. maxwellii showed cytotoxic activity with IC50 values of 3.546.0μg/mL. MeOH extracts (at 100μg/mL) of R. kerrii and S. auriculata could effectively scavenge DPPH free radicals (8283% inhibition) and superoxide anion radicals (79% and 88% inhibition). In the ORAC antioxidant assay, MeOH extracts of B. cristata, J. procumbens, R. kerrii, and S. auriculata exhibited activity with ORAC units of 3.13.9. © Georg Thieme Verlag KG Stuttgart · New York.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1055/s-0030-1250045