Vincenzo EneaJoan EllisFidel ZavalaDavid E. ArnotAchara AsavanichAoi MasudaIsabella QuakyiRuth S. NussenzweigNYU Langone Medical CenterMahidol UniversityNew York UniversityUniversity of Ghana2018-10-122018-10-121984-01-01Science. Vol.225, No.4662 (1984), 628-630003680752-s2.0-0021160478https://repository.li.mahidol.ac.th/handle/123456789/30722A clone of complementary DNA encoding the circumsporozoite (CS) protein of the human malaria parasite Plasmodium falciparum has been isolated by screening an Escherichia coli complementary DNA library with a monoclonal antibody to the CS protein. The DNA sequence of the complementary DNA insert encodes a four-amino acid sequence: proline-asparagine-alanine-asparagine, tandemly repeated 23 times. The CS β-lactamase fusion protein specifically binds monoclonal antibodies to the CS protein and inhibits the binding of these antibodies to native Plasmodium falciparum CS protein. These findings provide a basis for the development of a vaccine against Plasmodium falciparum malaria.Mahidol UniversityMultidisciplinaryArticleSCOPUS10.1126/science.6204384