J. M. Alonso-IñigoG. MazzinariM. Casañ-PallardóJ. I. Redondo-GarcíaJ. Viscasillas-MonteagudoA. Gutierrez-BautistaJ. Ramirez-FazP. Alonso-PérezS. Díaz-LobatoA. S. NetoO. Diaz-CambroneroP. Argente-NavarroM. Gama de AbreuP. PelosiM. J. SchultzIRCCS San Martino Polyclinic HospitalHospital Universitari i Politècnic La FeUniversità degli Studi di GenovaCleveland Clinic FoundationTechnische Universität DresdenHospital Israelita Albert EinsteinMahidol UniversityHospital General de CastellonNuffield Department of MedicineUniversidade de São PauloUniversidad Cardenal Herrera-CEUUniversidad de CórdobaAmsterdam UMC - University of AmsterdamNippon Gases HealthCare &amp; Oximesa NG2022-08-042022-08-042021-01-01Revista Espanola de Anestesiologia y Reanimacion. (2021)003493562-s2.0-85121352556https://repository.li.mahidol.ac.th/handle/20.500.14594/78547Background: The severe acute respiratory syndrome-coronavirus 2 pandemic pressure on healthcare systems can exhaust ventilator resources, especially where resources are restricted. Our objective was a rapid preclinical evaluation of a newly developed turbine-based ventilator, named the ACUTE-19, for invasive ventilation. Methods: Validation consisted of (a) testing tidal volume delivery in 11 simulated models, with various resistances and compliances; (b) comparison with a commercial ventilator (VIVO-50) adapting the United Kingdom Medicines and Healthcare products Regulatory Agency-recommendations for rapidly manufactured ventilators; and (c) in vivo testing in a sheep before and after inducing acute respiratory distress syndrome by saline lavage. Results: Differences in tidal volume in the simulated models were marginally different (largest difference 33 ml [95% CI 31 to 36]; P < .001). Plateau pressure was not different (−0.3 cmH2O [95% CI −0.9 to 0.3]; P = .409), and positive end-expiratory pressure was marginally different (0.3 cmH2O [95% CI 0.2 to 0.3]; P < .001) between the ACUTE-19 and the commercial ventilator. Bland-Altman analyses showed good agreement (mean bias −0.29 [limits of agreement 0.82 to −1.42], and mean bias 0.56 [limits of agreement 1.94 to −0.81], at a plateau pressure of 15 and 30 cmH2O, respectively). The ACUTE-19 achieved optimal oxygenation and ventilation before and after acute respiratory distress syndrome induction. Conclusions: The ACUTE-19 performed accurately in simulated and animal models yielding a comparable performance with a VIVO-50 commercial device. The ACUTE-19 can provide the basis for the development of a future affordable commercial ventilator.Mahidol UniversityMedicineArticleSCOPUS10.1016/j.redar.2021.09.008