Porntipa KorprasertthawornWandee UdomuksornKrongtong YoovathawornMahidol UniversityPrince of Songkla University2018-09-132018-09-132009-01-01Drug Metabolism and Pharmacokinetics. Vol.24, No.5 (2009), 482-48518800920134743672-s2.0-71449126247https://repository.li.mahidol.ac.th/handle/20.500.14594/28259The human UDP-glucuronosyltransferase, UGT1A9, catalyzes glucuronidation of various endobiotics and xenobiotics. In this study, we sequenced the promoter and exon 1 regions of the UGT1A9 gene in 93 Thai individuals and identified 7 genetic polymorphisms. The allele frequencies of all 3 novel single nucleotide polymorphisms (SNPs): 454A>G and 455A>C (N152A) and 760C>T (R254X) were 0.005. The other 4 known polymorphisms, -688A>C, 440T>C, 331C>T -118A(T)10AT (UGT1A9*1b), were identified and found to have frequencies of 0.124, 0.978, 0.968 and 0.532, respectively.Mahidol UniversityMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.2133/dmpk.24.482