Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common

White, Nicholas JGuo Qiao, LiQi, GaoLuzzatto, LucioMahidol University. Faculty of Tropical Medicine. Tropical Medicine Research Unit2017-09-112017-09-112017-09-112012Malaria Journal. Vol.11, (2012), 418https://repository.li.mahidol.ac.th/handle/20.500.14594/2803In areas of low malaria transmission, it is currently recommended that a single dose of primaquine (0.75 mg base/kg; 45 mg adult dose) be added to artemisinin combination treatment (ACT) in acute falciparum malaria to block malaria transmission. Review of studies of transmission-blocking activity based on the infectivity of patients or volunteers to anopheline mosquitoes, and of haemolytic toxicity in glucose 6-dehydrogenase (G6PD) deficient subjects, suggests that a lower primaquine dose (0.25 mg base/kg) would be safer and equally effective. This lower dose could be deployed together with ACTs without G6PD testing wherever use of a specific gametocytocide is indicated.engMahidol UniversityPlasmodium falciparumgametocytocideprimaquineG6PDOpen Access articleRationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is commonResearch ArticleBioMed Central