TBAI/TBHP-Mediated Cascade Cyclization toward Sulfonylated Indeno[1,2-c]quinolines

Jatuporn MeesinManat PohmakotrVichai ReutrakulDarunee SoorukramPawaret LeowanawatSaowanit SaithongChutima KuhakarnMahidol UniversityPrince of Songkla University2018-12-212019-03-142018-12-212019-03-142017-12-15Organic Letters. Vol.19, No.24 (2017), 6546-654915237052152370602-s2.0-85038411952https://repository.li.mahidol.ac.th/handle/20.500.14594/41727© 2017 American Chemical Society. Treatment of ortho-amino-substituted aryldiyne derivatives with sulfonyl hydrazides in the presence of tetrabutylammonium iodide (TBAI) and tert-butyl hydroperoxide (TBHP) led to a cascade cyclization reaction to yield sulfonylated indeno[1,2-c]quinolines in moderate to good yields. The features of the methodology include metal-free reaction, the ease of reagent handling, and a broad functional group tolerance.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryTBAI/TBHP-Mediated Cascade Cyclization toward Sulfonylated Indeno[1,2-c]quinolinesArticleSCOPUS10.1021/acs.orglett.7b03246