Sarath P D SenadeeraSuthep WiyakruttaChulabhorn MahidolSomsak RuchirawatPrasat KittakoopChulabhorn Graduate InstituteMahidol UniversityChulabhorn Research InstituteSouth Carolina Commission on Higher Education2018-06-112018-06-112012-09-21Organic and Biomolecular Chemistry. Vol.10, No.35 (2012), 7220-7226147705202-s2.0-84865204025https://repository.li.mahidol.ac.th/handle/20.500.14594/13610Azaphilone derivatives 1 and 2 and a novel tricyclic polyketide 3, together with a known azaphilone, austdiol (4), were isolated from the endophytic fungus Dothideomycete sp., which was isolated from a Thai medicinal plant, Tiliacora triandra. Compound 3 is the first polyketide having a tricyclic 6,6,6 ring system, which is similar to that of a terpenoid skeleton. The absolute configurations of stereogenic centers in 1-3 were addressed by Mosher's method and biosynthetic analogy with a known azaphilone isolated from the same fungus. Cytotoxic and antimicrobial activities of the isolated compounds were evaluated. © 2012 The Royal Society of Chemistry.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryArticleSCOPUS10.1039/c2ob25959a