W. SupanaranondY. SuputtamongkolT. M.E. DavisS. PukrittayakameeP. Teja-IsavadharmH. K. WebsterN. J. WhiteMahidol UniversityArmed Forces Research Institute of Medical Sciences, ThailandNuffield Department of Clinical Medicine2018-07-042018-07-041997-01-01Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.91, No.6 (1997), 694-696003592032-s2.0-0031446056https://repository.li.mahidol.ac.th/handle/20.500.14594/17991Quinine dihydrochloride (10 mg salt/kg infused over one hour) and mefloquine (15 mg base/kg) were given simultaneously to 13 adults with uncomplicated falciparum malaria. Supine and standing blood pressures were recorded and the electrocardiogram monitored. Plasma concentrations of the 2 drugs were similar to those reported previously for the 2 compounds given individually to a similar group of patients. Although postural hypotension was common (6 cases before treatment and 7 after) and the electrocardiogram QT(c) interval was prolonged by a mean of 12% (SD = 8) following drug treatment, there was no evidence of a clinically significant cardiovascular pharmacodynamic interaction between these 2 structurally related antimalarial compounds.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.1016/S0035-9203(97)90528-9