Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual Plasmodium falciparum

Chery-Karschney L.Patrapuvich R.Mudeppa D.G.Kokkonda S.Chakrabarti R.Sriwichai P.O'Connor R.M.Rathod P.K.White J.Mahidol University2024-02-172024-02-172024-02-07Antimicrobial agents and chemotherapy Vol.68 No.2 (2024) , e0068423https://repository.li.mahidol.ac.th/handle/20.500.14594/97227Due to the spread of resistance to front-line artemisinin derivatives worldwide, there is a need for new antimalarials. Tartrolon E (TrtE), a secondary metabolite of a symbiotic bacterium of marine bivalve mollusks, is a promising antimalarial because it inhibits the growth of sexual and asexual blood stages of Plasmodium falciparum at sub-nanomolar levels. The potency of TrtE warrants further investigation into its mechanism of action, cytotoxicity, and ease with which parasites may evolve resistance to it.Pharmacology, Toxicology and PharmaceuticsMedicineTartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual Plasmodium falciparumArticleSCOPUS10.1128/aac.00684-232-s2.0-851845210841098659638193705