Luis H. CamachoPolarat WilairatanaGünter WeissMarco A. MercaderGary M. BrittenhamSornchai LooareesuwanVictor R. GordeukGeorge Washington University Medical CenterMahidol UniversityUniversity Hospital InnsbruckColumbia University, College of Physicians and SurgeonsMemorial Sloan-Kettering Cancer Center2018-09-072018-09-071999-08-16Tropical Medicine and International Health. Vol.4, No.7 (1999), 471-475136022762-s2.0-0032796484https://repository.li.mahidol.ac.th/handle/20.500.14594/25434To examine a possible relationship between the immune response and haematological recovery after acute falciparum malaria, we followed peripheral blood eosinophil counts and haemoglobin concentrations for 4 weeks after starting effective treatment in 70 adult Thai patients. Eosinophils are induced by Th-2 cytokines as well as other stimuli. Eosinophil counts were elevated in only 8 (11%) of the subjects at presentation, but were increased in 65 (93%) by day 7. Eosinophil counts then decreased markedly by day 14, followed by a second increase until day 28. A significant positive correlation was found between peak eosinophil counts on day 7 and the haemoglobin concentration on day 28, both in 16 subjects without stool parasites (r = 0.65, P = 0.006) and in 54 patients with stool parasites (r = 0.32; P = 0.0019). These results suggest that a robust eosinophilic response shortly after completing antimalarial therapy predicts a good recovery from malaria-associated anaemia.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.1046/j.1365-3156.1999.00426.x