Norased NasongkiaBo ChenNichole MacaraegMegan E. FoxJean M.J. FréchetFrancis C. SzokaUniversity of California, San FranciscoUniversity of California, BerkeleyMahidol University2018-09-132018-09-132009-03-25Journal of the American Chemical Society. Vol.131, No.11 (2009), 3842-3843000278632-s2.0-67849104970https://repository.li.mahidol.ac.th/handle/20.500.14594/27263The ability of a polymer to reptate through a nanopore has an influence on its circulatory half-life and biodistribution, since many physiological barriers contain nanopores. A cyclic polymer lacks chain ends, and therefore, cyclic polymers with molecular weights greater than the renal threshold for elimination should circulate longer than their linear-polymer counterparts when injected into animals. As predicted, radiolabeled cyclic polymers with molecular weights greater than the renal threshold have longer blood circulation times in mice than do linear polymers of comparable molecular weight. © 2009 American Chemical Society.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemical EngineeringChemistryArticleSCOPUS10.1021/ja900062u